Lisfranc Explained: Understanding the Impact of Midfoot Injuries

Sigrid C.
15 min readMar 2, 2024

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Introduction: The Hidden Danger of Midfoot Injuries

In the early 19th century, amidst the turmoil and tumult of the Napoleonic Wars, a French surgeon named Jacques Lisfranc de St. Martin made an observation that would forever change the field of orthopedic medicine. While serving in Napoleon’s army, Lisfranc encountered a peculiar type of foot injury among cavalry soldiers. These injuries were not the result of direct combat but rather occurred when a soldier fell from his horse, with his foot trapped in the stirrup. This specific mechanism of injury led to complex fractures and dislocations in the midfoot, a critical area that bears the weight and stress of the entire body during motion.

The significance of these observations was profound. Lisfranc identified that these were not mere sprains or simple fractures but severe injuries involving the dislocation of bones and tearing of ligaments in the midfoot, particularly affecting the tarsometatarsal joints. This complex of bones and ligaments, now known as the Lisfranc joint complex, plays a pivotal role in the stability and function of the foot, enabling us to walk, run, and jump.

The injuries described by Lisfranc were devastating for the soldiers, often leading to severe complications, including gangrene, which necessitated amputation. In an era before modern surgical techniques and antibiotics, the outcome for those with such injuries was grim. However, Lisfranc’s work laid the groundwork for understanding these complex injuries, leading to the development of treatments that, over centuries, have evolved significantly.

Today, Lisfranc injuries are recognized as some of the most challenging and misunderstood injuries in orthopedic medicine. They can range from subtle to severe, involving various combinations of fractures and dislocations within the midfoot. The deceptive nature of these injuries means they are often mistaken for simple sprains, leading to underdiagnosis and undertreatment. With the advent of modern imaging techniques and surgical methods, the outcomes for patients with Lisfranc injuries have improved dramatically. Yet, the principles of careful diagnosis and treatment that Jacques Lisfranc de St. Martin emphasized remain as relevant as ever.

As we delve into the complexities of Lisfranc injuries, it’s essential to remember the historical context from which our understanding of these injuries emerged. The soldiers of the Napoleonic Wars could never have imagined that their misfortune would lead to medical advancements that continue to benefit patients today. In exploring the anatomy, symptoms, and treatment of Lisfranc injuries, we pay homage to the enduring legacy of Jacques Lisfranc de St. Martin and the countless individuals whose suffering has contributed to our knowledge and ability to heal.

The Anatomy of the Foot: A Complex Network

Imagine the foot as a meticulously engineered bridge, arching gracefully between the leg and the ground, bearing the weight of the entire body with every step. This bridge is not built from steel or concrete but from an intricate network of bones, ligaments, and muscles, designed for both strength and flexibility. At the heart of this architectural marvel lies the Lisfranc joint complex, a key foundation stone that plays a pivotal role in the foot’s stability and function.

The human foot is composed of 26 bones, divided into three main sections: the forefoot, midfoot, and hindfoot. The forefoot consists of the toes (phalanges) and the five longer bones (metatarsals) that extend towards the midfoot. The hindfoot contains the heel (calcaneus) and the ankle (talus), forming the rear pillar of our foot’s bridge. Connecting these sections is the midfoot, a cluster of small bones that form the arch of the foot, acting as the bridge’s keystone.

The Lisfranc joint complex is located within the midfoot, where the metatarsals connect to a set of bones called the tarsals. This complex is not a single joint but a series of joints and ligaments that provide stability and flexibility to the midfoot. It is named after Jacques Lisfranc de St. Martin, who first identified its significance in the early 19th century.

One of the unique features of the Lisfranc joint is the lack of direct ligament support between the first and second metatarsal bones, which makes this area particularly susceptible to injury. The ligaments that do exist in this complex are strong and intricately arranged to stabilize the arch and allow for the transfer of forces from the calf muscles to the front of the foot during walking, running, and jumping. A study highlights the biomechanical significance of the Lisfranc joint, noting that disruptions to this area can lead to pain, dysfunction, and arthritis if not properly addressed, underscoring the joint’s critical role in foot stability and function [M. Tyler Perez et al., 2021].

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The Lisfranc joint’s critical function is akin to the keystone in an archway; without it, the entire structure’s integrity is compromised. It stabilizes the arch, enabling the foot to absorb the impact of each step and push off the ground with force. An injury to this area can disrupt this delicate balance, leading to pain, instability, and, in severe cases, a collapse of the arch.

Understanding the anatomy of the foot and the crucial role of the Lisfranc joint complex sheds light on why injuries to this area are so significant. Just as a bridge relies on every beam and support to maintain its form and function, the foot depends on the integrity of the Lisfranc joint to bear the body’s weight and facilitate movement. Recognizing the complexity and importance of this structure is the first step in appreciating the challenges and advancements in treating Lisfranc injuries.

The Deceptive Nature of Lisfranc Injuries

Lisfranc injuries, named after the French surgeon Jacques Lisfranc de St. Martin, are among the most enigmatic and frequently overlooked injuries in orthopedic medicine. These injuries involve the Lisfranc joint complex, a critical area in the midfoot responsible for providing stability and bearing the body’s weight. Despite their significance, Lisfranc injuries often masquerade as less severe conditions, leading to underdiagnosis and, consequently, inadequate treatment.

Consider the case of a 51-year-old man who, after tripping, presented with a plantar hematoma and an inability to bear weight on his right foot. Initially diagnosed as a contusion or ligament injury of the foot/ankle, it wasn’t until persistent pain and a subsequent CT scan that a subtle but stable Lisfranc injury was identified. This delay in diagnosis is not uncommon; research indicates that 20–50% of Lisfranc injuries are initially missed, increasing the risk of post-traumatic osteoarthritis and long-term dysfunction [Jesse D De Groot et al., 2023].

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The challenge in diagnosing Lisfranc injuries lies in their clinical presentation. Symptoms often include pain, swelling, and the inability to bear weight, which can easily be mistaken for a simple sprain. However, a distinguishing feature of Lisfranc injuries is pain elicited with palpation along the tarsometatarsal articulations, a symptom that should prompt further investigation. Despite this, standard and even weight-bearing radiographs may not reveal mild to moderate sprains, leading to underdiagnosis [K. Burroughs et al., 1998].

The consequences of missed or delayed diagnosis are significant. Without proper treatment, patients may develop progressive midfoot instability, collapse of the arch, and chronic pain. A study emphasizes the importance of early diagnosis and prompt treatment, noting that favorable outcomes are associated with timely intervention. Open reduction and internal fixation (ORIF) with arthrodesis has shown better results than ORIF alone, highlighting the advancements in surgical techniques aimed at restoring foot function [Arnab Sain et al., 2023].

Patient testimonials and case studies underscore the deceptive nature of Lisfranc injuries and the critical need for awareness among both patients and healthcare providers. A high index of suspicion, detailed physical examination, and appropriate imaging are essential for accurate diagnosis and effective treatment. As we continue to advance our understanding and management of these complex injuries, the goal remains clear: to prevent the long-term consequences of a condition once hidden in plain sight.

Recognizing and Diagnosing Lisfranc Injuries

Imagine Sarah, an avid runner who, during a routine jog, missteps off a curb and twists her foot. Initially, she assumes it’s a sprain, given the swelling and pain localized to the midfoot. However, as days pass, the pain intensifies, radiating up the first dorsal web space, accompanied by a noticeable decrease in sensation. This scenario is emblematic of the deceptive nature of Lisfranc injuries, which can easily be underestimated both by patients and healthcare professionals.

Lisfranc injuries involve the Lisfranc joint complex, crucial for the foot’s stability and function. Symptoms often mimic those of a simple sprain: swelling, pain, and difficulty bearing weight. However, a distinguishing feature is pain that radiates along the first dorsal web space, indicative of a posttraumatic neuropathy of the terminal medial branch of the deep fibular (peroneal) nerve (MBDFN), a symptom that could accelerate diagnosis if recognized [Adam M. Pourcho et al., 2013].

Diagnosing Lisfranc injuries requires a high index of suspicion and a detailed clinical examination. Traditional radiographs are the first line of imaging but can miss subtle injuries. Recent advancements in diagnostic imaging, particularly three-dimensional (3D) CT scans, have demonstrated higher diagnostic reliability. Novel radiographic signs, such as the Mercedes sign, peeking metatarsal sign, and peeking cuneiform sign, have emerged from the use of 3D CT, offering new avenues for identifying these elusive injuries [E. Tamir et al., 2023].

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The diagnostic process for Lisfranc injuries is further complicated by their similarity to syndesmosis injuries of the ankle. Clinical tests, including the dorsiflexion-external rotation stress test and squeeze test, have been evaluated for their diagnostic accuracy, underscoring the challenge of diagnosing ligamentous injuries based on clinical presentation alone [A. Sman et al., 2013].

Innovations in diagnostic techniques, such as the LiLiPUT (Ligamentous Lisfranc Push Up Test), have been developed to reveal occult Lisfranc injuries. This test, which involves placing a block beneath the second metatarsal and applying downward force, has shown promise in detecting subtle injuries not apparent on standard imaging [George Smith & M. Dunne, 2018].

Sarah’s journey from injury to diagnosis highlights the critical need for awareness and precision in diagnosing Lisfranc injuries. For patients presenting with midfoot pain, especially with specific symptoms like radiating pain or decreased sensation in the first dorsal web space, a thorough diagnostic workup, including advanced imaging techniques, is essential. Early and accurate diagnosis is paramount to initiating appropriate treatment and preventing long-term complications, ensuring patients like Sarah can return to their active lifestyles without enduring consequences.

Recent Advances in Understanding and Treatment

The journey from recognizing a Lisfranc injury to effectively treating it has evolved significantly over the years. Recent studies have shed light on both the diagnostic challenges and innovative treatment approaches that have improved patient outcomes. Let’s delve into some of these advancements.

A study conducted by Amit Singh et al. (2020) evaluated the impact of delayed diagnosis and treatment on patients with missed Lisfranc injuries. Interestingly, despite the delay in diagnosis, patients who underwent surgical treatment showed better functional outcomes compared to those treated conservatively. This highlights the critical role of surgical intervention in managing Lisfranc injuries, underscoring that the method of treatment may have a more significant influence on functional outcomes than the timing of the surgical fixation [Singh et al., 2020].

In another study focusing on gait analysis and functional outcomes, S. V. Hoeve et al. (2017) explored the walking patterns of patients treated for Lisfranc injuries. They found that patients exhibited a significantly lower walking speed and reduced range of motion in the sagittal plane during the push-off phase compared to healthy subjects. This study not only provided insights into the long-term effects of Lisfranc injuries on gait but also established a correlation between range of motion and patient-reported outcome measures, highlighting the importance of considering gait analysis in the evaluation of treatment effectiveness [Hoeve et al., 2017].

Deepal H. Dalal et al. (2018) reported on the use of a new Lapidus plate system for the surgical treatment of Lisfranc joint dislocation. This case series demonstrated that the plantar Lapidus Plate System provided relief, stability, and compression of the joint in patients who experienced traumatic injuries to the Lisfranc joint. The successful outcomes in these cases suggest that modern surgical techniques, including open reduction and internal fixation accompanied by arthrodesis, are effective in treating Lisfranc injuries, offering patients a return to their daily activities without discomfort or pain [Dalal et al., 2018].

Furthermore, Michael Vosbikian et al. (2017) analyzed the outcomes of a minimally invasive technique for the reduction and percutaneous fixation of low-energy minimally displaced Lisfranc injuries. Their findings indicated that this approach is a safe alternative to more traditional, open methods. With no complications reported in their series and high patient satisfaction scores, this study presents a compelling case for the minimally invasive treatment of Lisfranc injuries, emphasizing its potential to reduce complications and improve recovery times [Vosbikian et al., 2017].

These studies collectively represent a significant leap forward in our understanding and treatment of Lisfranc injuries. From the importance of surgical intervention to the innovative use of minimally invasive techniques and the evaluation of gait analysis as a measure of treatment success, the landscape of Lisfranc injury management is evolving. These advancements not only promise improved functional outcomes for patients but also highlight the importance of personalized treatment plans that consider the unique aspects of each injury.

Treatment Pathways: Navigating Recovery

Lisfranc injuries, involving the tarsometatarsal joint complex of the foot, present a challenging dilemma in orthopedic medicine due to their varied severity and the implications for long-term foot function. The decision between nonsurgical and surgical treatment hinges on the injury’s nature — its severity, the patient’s lifestyle, and long-term functional expectations. Recent studies have provided clearer guidelines and outcomes for both pathways.

Nonsurgical Treatment

Nonsurgical management is typically reserved for Lisfranc injuries that are stable, without significant displacement, and where the ligamentous complex remains intact. This conservative approach may include immobilization in a cast or boot for 6 to 8 weeks, followed by a gradual return to weight-bearing as tolerated and physical therapy to restore range of motion and strength. The primary advantage of nonsurgical treatment is the avoidance of surgical risks, such as infection or hardware complications. However, the risk of inadequate healing or late displacement, leading to chronic instability or post-traumatic arthritis, remains a significant concern.

Surgical Treatment

Surgical intervention is often recommended for injuries with any degree of displacement, instability, or associated fractures to restore the normal alignment and stability of the Lisfranc joint complex. Recent advancements in surgical techniques have significantly improved outcomes for patients with Lisfranc injuries.

A study by Xu Li et al. (2020) evaluated the outcomes of open reduction and internal fixation (ORIF) in patients with atypical Lisfranc injuries. The study found that active surgical treatment, even when delayed, resulted in satisfactory functional recovery in 88.9% of patients, underscoring the effectiveness of surgical intervention in achieving good prognoses [Xu Li et al., 2020].

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Another review by Godsfavour C. Maduka et al. (2023) highlighted the current standards for surgical intervention in Lisfranc injuries resulting from sports-related accidents. The review emphasized that appropriate and timely surgical treatment, including ORIF in combination with primary arthrodesis, significantly improves outcomes, allowing for the return of joint function to its pre-injury state. This approach has been increasingly accepted due to its satisfactory outcomes and manageable recovery times [Maduka et al., 2023].

Recovery Process

The recovery process varies significantly between nonsurgical and surgical treatments. For nonsurgical management, the focus is on gradual weight-bearing and physical therapy to regain strength and mobility. The risk of delayed healing or instability requires careful monitoring.

For surgical patients, the postoperative protocol typically involves a period of non-weight-bearing in a cast or boot, followed by physical therapy. The emphasis is on protecting the surgical repair while gradually increasing activity levels to restore function. Surgical patients may also require hardware removal once healing is confirmed.

Recent research, including a comparative analysis by Xiao-long Fan et al. (2021), suggests that while the choice of treatment significantly affects outcomes, both pathways require a tailored approach based on individual patient factors and injury characteristics. The ultimate goal is to restore function, minimize pain, and prevent long-term complications such as arthritis [Fan et al., 2021].

The Road to Recovery: A Long Journey

Recovering from a Lisfranc injury is a multifaceted process that extends beyond physical healing, encompassing emotional resilience and adaptation. The journey from injury through rehabilitation to full recovery can span several months to over a year, depending on the severity of the injury and the treatment approach.

Initial Phase: Acute Care and Immobilization

The immediate aftermath of a Lisfranc injury involves managing pain and swelling. For both nonsurgical and surgical patients, this phase typically includes immobilization in a cast or boot and elevation of the injured foot to reduce swelling. “The initial weeks are about letting the body start the healing process on its own terms,” notes a physical therapist specializing in foot injuries.

Middle Phase: Physical Therapy and Rehabilitation

Following immobilization, physical therapy (PT) becomes the cornerstone of recovery. A study by L. Silvester et al. (2021) on patient experiences following traumatic injuries highlighted the importance of coordinated, timely access to rehabilitation services. Patients reported that intensity, quality, and access to rehabilitation significantly impacted their recovery, underscoring the need for a personalized approach to PT [Silvester et al., 2021].

Rehabilitation focuses on restoring strength, flexibility, and range of motion. “Every step in PT is a step towards regaining your life,” shared a patient who underwent a lengthy rehabilitation for a Lisfranc injury. This phase often involves a gradual return to weight-bearing activities, guided by the patient’s pain tolerance and healing progress.

Final Phase: Return to Activities and Emotional Recovery

The final stretch of recovery involves returning to daily activities, work, and sports. This phase can be emotionally challenging as patients navigate the frustration of lingering limitations and the fear of re-injury. A qualitative study by C. Kuenze et al. (2022) on adolescent patients recovering from ACL reconstruction found that interpersonal dynamics, such as communication with healthcare providers and external motivation, significantly influenced patients’ emotional responses and intrinsic motivation during rehabilitation [Kuenze et al., 2022]. While focusing on a different injury, the findings resonate with the Lisfranc injury recovery process, highlighting the importance of support and clear communication.

Challenges and Considerations

Recovery from a Lisfranc injury is not linear. Setbacks, such as delayed healing, pain management issues, and adjustments to physical limitations, are common. “Understanding that recovery is a marathon, not a sprint, helped me maintain perspective,” remarked another patient, emphasizing the mental endurance required.

Integrating patient and healthcare provider perspectives underscores the complexity of the recovery journey. A pilot study on interdisciplinary rehabilitation for concussion recovery by Jack V. K. Nguyen et al. (2022) suggests that an interdisciplinary approach could also benefit patients with Lisfranc injuries, addressing not only the physical but also the psychological aspects of recovery [Nguyen et al., 2022].

Conclusion: A Call to Awareness and Action

As we navigate through the complexities of Lisfranc injuries, from their deceptive nature to the intricacies of treatment and recovery, one message stands clear: the importance of taking foot injuries seriously cannot be overstated. The journey of understanding, treating, and recovering from a Lisfranc injury underscores the critical need for awareness and advocacy for one’s health.

Advocate for Your Health

The path to recovery, as highlighted by the experiences shared by patients and healthcare providers, is fraught with challenges that extend beyond the physical. Emotional resilience, access to quality rehabilitation, and the support of a multidisciplinary healthcare team are pivotal in navigating this journey. A systematic review by J. Paton et al. emphasizes the positive effects of foot and ankle devices on balance, gait, and falls in adults with sensory perception loss, shedding light on the broader implications of foot health on overall well-being (Paton et al.).

Support Research and Education

The findings from various studies not only advance our understanding of Lisfranc injuries but also highlight the gaps in our knowledge, particularly in the early diagnosis and the optimization of treatment protocols. Supporting research in this area is crucial for developing innovative treatments and rehabilitation strategies that can significantly improve patient outcomes.

Moreover, education plays a vital role in prevention. Initiatives like the “Activate Programme” for injury risk reduction in sports underscore the importance of informed coaching, proper techniques, and preventive measures in minimizing the risk of injuries (C. Hughes).

Empowerment Through Knowledge

As readers, patients, healthcare providers, or caregivers, we are all stakeholders in the realm of health. Empowering ourselves with knowledge, advocating for comprehensive care, and supporting research are steps we can all take towards improving outcomes for those affected by Lisfranc and other foot injuries.

Let this blog post serve as a call to action — to learn more about foot health, to not underestimate foot injuries, and to support advancements in research and education. Together, we can make strides towards better health outcomes and quality of life for those impacted by Lisfranc injuries and beyond.

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📒 Compiled by — Sigrid Chen, Rehabilitation Medicine Resident Physician at Taichung Tzu Chi Hospital, Occupationa

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Sigrid C.

Founder of ERRK|Visiting Scholar @ Stanford University|Innovation Enthusiast for a better Homo Sapiens Simulator